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CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50 =12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and …

CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation. [1] CK-666 is a cell-permeable inhibitor of actin assembly mediated by actin …

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Structrual studies indicate that CK-666 targets a pocket formed between subdomain 4 of Arp2 and subdomain 1 of Arp3, preventing Arp2/3 from shifting into an active conformation upon N-WASP …

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